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Rats with naturally high stress levels were far more likely to self-administer cannabis when given access. Behavioral testing showed that baseline stress hormones were the strongest predictor of cannabis-seeking behavior. Lower cognitive flexibility and low endocannabinoid levels also contributed to
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Rats with naturally high stress levels were far more likely to self-administer cannabis when given access. Behavioral testing showed that baseline stress hormones were the strongest predictor of cannabis-seeking behavior. Lower cognitive flexibility and low endocannabinoid levels also contributed to increased use. The results hint at possible early indicators of vulnerability to drug misuse.